KIT mutations and CD117 overexpression are markers of better progression-free survival in vulvar melanomas

D. Dias-Santagata, M. A. Selim, Y. Su, Y. Peng, R. Vollmer, A. Chłopik, G. Tell-Marti, K. M. Paral, S. C. Shalin, C. R. Shea, S. Puig, M. T. Fernandez-Figueras, W. Biernat, J. Ryś, A. Marszalek, M. P. Hoang

    Research output: Contribution to journalArticleResearchpeer-review

    6 Citations (Scopus)

    Abstract

    © 2017 British Association of Dermatologists Background: Few studies have addressed prognostic markers and none has correlated molecular status and prognosis in vulvar melanomas. Objectives: To evaluate the clinicopathological features of 95 cases of vulvar melanoma. Methods: p53, CD117, Ki-67, neurofibromin, brafv600e and nrasq61r immunostains, and molecular analyses by either targeted next-generation or direct sequencing, were performed on available archival materials. Results: Molecular testing detected mutations in KIT (44%), BRAF (25%), NF1 (22%), TP53 (17%), NRAS (9%) and TERT promoter (9%). Co-mutation of KIT and NF1 and of KIT and NRAS were identified in two and one cases, respectively. KIT mutations were significantly associated with better progression-free survival in univariate analyses. In multivariate analyses CD117 expression was significantly associated with better progression-free survival. Tumour thickness was significantly associated with worse progression-free and overall survival, and perineural invasion significantly correlated with reduced melanoma-specific survival and reduced overall survival. Cases were from multiple centres and only a subset of samples was available for molecular testing. Conclusions: KIT mutations and CD117 overexpression are markers of better progression-free survival. In addition to its prognostic value, molecular testing may identify cases that might respond to targeted agents or immunotherapeutic approaches.
    Original languageEnglish
    Pages (from-to)1376-1384
    JournalBritish Journal of Dermatology
    Volume177
    Issue number5
    DOIs
    Publication statusPublished - 1 Nov 2017

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