Kinetic studies of N-allenic analogues of tryptamine as monoamine oxidase inhibitors

V. Perez, J. L. Marco, E. Fernandez-Alvarez, M. Unzeta

Research output: Contribution to journalArticleResearchpeer-review

12 Citations (Scopus)

Abstract

A series of N-allenic analogues of tryptamine in which the side chain is located at the 2 position of the indole ring, but which differed in the ring and side-chain nitrogen substituents, were assayed kinetically as MAO A and MAO B inhibitors. All the compounds studied were mechanism-based inhibitors. The kinetic constants of each inhibition step K(i) and k(i), were determined for both MAO A and B. The data obtained indicated that these allenic derivatives show a greater selectivity and potency towards MAO A as inhibitors than the corresponding acetylenic derivatives.
Original languageEnglish
Pages (from-to)718-722
JournalJournal of Pharmacy and Pharmacology
Volume48
Issue number7
DOIs
Publication statusPublished - 1 Jan 1996

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