Juvenile neuroaxonal dystrophy in a Rottweiler: Accumulation of synaptic proteins in dystrophic axons

Marti Pumarola Batlle, S. Sisó, I. Ferrer

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    22 Citations (Scopus)

    Abstract

    Dystrophic axons in a 2-year-old male Rottweiler with neuroaxonal dystrophy have shown synaptophysin, synapsin-I, synaptosomal-associated protein of 25 kDa (SNAP-25), Rab 3a, and α-synuclein immunoreactivity. Similar findings have been observed in isolated dystrophic axons in the nuclei gracillis and cunneatus in five dogs aged between 14 and 18 years. Abnormal expression of integral synaptic vesicle, synaptic vesicle-associated presynaptic plasma membrane and cytosolic proteins, which participate in the trafficking, docking and fusion of the synaptic vesicle to the plasma membrane, suggest severe disruption of axonal transport in dystrophic axons in canine neuroaxonal dystrophy.
    Original languageEnglish
    Pages (from-to)501-504
    JournalActa Neuropathologica
    Volume102
    Issue number5
    DOIs
    Publication statusPublished - 1 Jan 2001

    Keywords

    • Neuroaxonal dystrophy
    • Rottweiler
    • SNAP-25
    • Synapsin-I
    • Synaptophysin

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