JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis

Luz Martínez-Avilés; Carles Besses; Alberto Álvarez-Larrán; Francisco Cervantes; Juan Carlos Hernández-Boluda; Beatriz Bellosillo

doi:10.3324/haematol.12011

JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis

Luz Martínez-Avilés, Carles Besses, Alberto Álvarez-Larrán, Francisco Cervantes, Juan Carlos Hernández-Boluda, Beatriz Bellosillo

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Abstract

JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.

Original language	English
Pages (from-to)	1717-1718
Journal	Haematologica
Volume	92
Issue number	12
DOIs	https://doi.org/10.3324/haematol.12011
Publication status	Published - 1 Dec 2007

Keywords

Erythrocytosis
Exon 12
JAK2 mutation
PV
V617F mutation

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10.3324/haematol.12011

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title = "JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis",

abstract = "JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.",

keywords = "Erythrocytosis, Exon 12, JAK2 mutation, PV, V617F mutation",

author = "Luz Mart{\'i}nez-Avil{\'e}s and Carles Besses and Alberto {\'A}lvarez-Larr{\'a}n and Francisco Cervantes and Hern{\'a}ndez-Boluda, {Juan Carlos} and Beatriz Bellosillo",

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T1 - JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis

AU - Martínez-Avilés, Luz

AU - Besses, Carles

AU - Álvarez-Larrán, Alberto

AU - Cervantes, Francisco

AU - Hernández-Boluda, Juan Carlos

AU - Bellosillo, Beatriz

PY - 2007/12/1

Y1 - 2007/12/1

N2 - JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.

AB - JAK2 exon 12 mutations were detected in 4 out of 20 polycythemia vera and idiopathic erythrocytosis V617F-negative patients and were only present in the myeloid lineage. Initial hematologic data of these patients differ from those of V617F-positive patients, but there is no difference in thrombotic development and myelofibrotic transformation.

KW - Erythrocytosis

KW - Exon 12

KW - JAK2 mutation

KW - PV

KW - V617F mutation

U2 - 10.3324/haematol.12011

DO - 10.3324/haematol.12011

M3 - Article

VL - 92

SP - 1717

EP - 1718

IS - 12

ER -

JAK2 exon 12 mutations in polycythemia vera or idiopathic erythrocytosis

Abstract

Keywords

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