IVF/ICSI with or without preimplantation genetic screening for aneuploidy in couples without genetic disorders: A systematic review and meta-analysis

Miguel A. Checa, Pablo Alonso-Coello, Ivan Solà, Ana Robles, Ramón Carreras, Juan Balasch

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29 Citations (Scopus)

Abstract

Purpose: To assess the efficacy of preimplantation genetic screening to increase ongoing pregnancy rates in couples without known genetic disorders. Methods: Systematic review and meta-analysis of randomized controlled trials. Two reviewers independently determined study eligibility and extracted data. Results: Ten randomized trials (1,512 women) were included. The quality of evidence was moderate. Meta-analyses using a random-effects model suggest that PGS has a lower rate of ongoing pregnancies (risk ratio=0.73, 95% confidence interval 0.62-0.87) and a lower rate of live births (risk ratio=0.76, 95% confidence interval 0.64-0.91) than standard in vitro fertilization/ intracytoplasmic sperm injection. Conclusions: In women with poor prognosis or in general in vitro fertilization program, in vitro fertilization/ intracytoplasmic sperm injection with preimplantation genetic screening for aneuploidy does not increase but instead was associated with lower rates of ongoing pregnancies and live births. The use of preimplantation genetic screening in daily practice does not appear to be justified. © 2009 Springer Science+Business Media, LLC.
Original languageEnglish
Pages (from-to)273-283
JournalJournal of Assisted Reproduction and Genetics
Volume26
Issue number5
DOIs
Publication statusPublished - 1 May 2009

Keywords

  • Advanced maternal age
  • Aneuploidy
  • IVF/ICSI
  • Meta-analysis
  • Preimplantation genetic screening
  • Recurrent pregnancy loss
  • Repeated IVF failure

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