Ischemic preconditioning: Tolerance to hepatic ischemia-reperfusion injury

A. Serafín, L. Fernández-Zabalegui, N. Prats, Z. Y. Wu, Joan Roselló-Catafau, C. Peralta

    Research output: Contribution to journalReview articleResearchpeer-review

    38 Citations (Scopus)

    Abstract

    Hepatic ischemia-reperfusion (I/R) injury still remains an unresolved problem in both liver resectional surgery and liver transplantation and may be responsible for liver failure, lung injury and death. The current review summarizes the findings reported to date on the effectiveness of ischemic preconditioning against liver and lung damage associated with hepatic I/R injury and the underlying protective mechanisms. The effect of ischemic preconditioning on the mechanisms potentially involved in hepatic I/R injury, including alterations in energy metabolism, neutrophil accumulation, microcirculatory disturbances, formation of proinflammatory mediators, such as endothelin and tumor necrosis factor-alpha, and reactive oxygen species generation have been evaluated. In this review, we address the role of preconditioning in the increased vulnerability of fatty livers to hepatic I/R injury. The effectiveness of ischemic preconditioning versus pharmacological strategies that could simulate the benefits of liver preconditioning has been also discussed.
    Original languageEnglish
    Pages (from-to)281-289
    JournalHistology and Histopathology
    Volume19
    Issue number1
    Publication statusPublished - 1 Jan 2004

    Keywords

    • Ischemia
    • Liver
    • Preconditioning
    • Reperfusion
    • Steatosis

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