Is ZMP the toxic metabolite in Lesch-Nyhan disease?

Pharmacology, Toxicology and Pharmaceutical Science

• Lesch Nyhan Syndrome 100%
• Guanine 83%
• Hypoxanthine 83%
• Enzyme 66%
• Toxin 66%
• Hydroxymethylglutaryl Coenzyme A Reductase Kinase 50%
• Dopamine 33%
• Adenylosuccinate Lyase 33%
• Neurologic Disease 16%
• Human 16%
• Cyclic AMP Dependent Protein Kinase 16%
• Guanosine Phosphate 16%
• Toxic Agent 16%
• Purine 16%
• Inosine Phosphate 16%
• Catecholamine 16%
• Xanthine 16%
• Apoptosis 16%
• Phosphoribosyl Pyrophosphate 16%

Biochemistry, Genetics and Molecular Biology

• Guanine 83%
• Lysozyme 66%
• AMP-activated Protein Kinase 50%
• Cell Viability 33%
• Nucleotide 33%
• Riboside 33%
• Adenylosuccinate Lyase 33%
• Human 16%
• Morphology 16%
• Apoptosis 16%
• Oxidative Phosphorylation 16%
• X Chromosome 16%
• Pleiotropy 16%
• Mitochondrial Respiration 16%
• Dopamine Brain Level 16%
• Dopamine Metabolism 16%
• Mental Retardation 16%
• Catecholamine Synthesis 16%
• Purine Synthesis 16%
• Energy 16%
• Genetics 16%
• Regulatory Mechanism 16%