Is there a relationship between prostate volume and Gleason score?

Maria Carmen Mir, Jacques Planas, Carles Xavier Raventos, Ines Maria De Torres, Enrique Trilla, Lluis Cecchini, Anna Orsola, Juan Morote

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)


OBJECTIVES: To review the relationship between the Gleason grade and prostate volume in biopsy and radical prostatectomy (RP) specimens, and thus assess the hypothesis that smaller prostates have a greater incidence of high-grade tumours. PATIENTS AND METHODS: We selected 390 patients who had RP at our institution, with a prostate-specific antigen (PSA) level of <10 ng/mL and who had not had hormonal therapy. We retrospectively reviewed the data for transrectal ultrasonography (TRUS)-guided prostate biopsies from these patients and the RP specimens. Indications for biopsy included a PSA level of ≥4 ng/mL or an abnormal digital rectal examination. High-grade tumours were defined as having a Gleason score of ≥7. RESULTS: The TRUS volume was statistically related to the rate of high-grade tumours at biopsy and RP. On multivariate analyses, TRUS volume was a significant predictor of high-grade tumour for biopsy and RP specimens, with an inverse relationship between high-grade tumours and prostate volume for biopsy and RP specimens. CONCLUSIONS: Our data suggest that there is a relationship between the rate of high-grade tumours and prostate volume even in biopsy and RP specimens and it is not an artefact related to the biopsy. © 2008 The Authors.
Original languageEnglish
Pages (from-to)563-565
JournalBJU International
Issue number5
Publication statusPublished - 1 Sept 2008


  • Biopsy
  • Gleason score
  • High grade
  • Prostate neoplasia


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