Is membrane homeostasis the missing link between inflammation and neurodegenerative diseases?

Natalia Sánchez De Groot, Marc Torrent Burgas

Research output: Contribution to journalArticleResearchpeer-review

18 Citations (Scopus)

Abstract

© 2015 Springer Basel. Systemic inflammation and infections are associated with neurodegenerative diseases. Unfortunately, the molecular bases of this link are still largely undiscovered. We, therefore, review how inflammatory processes can imbalance membrane homeostasis and theorize how this may have an effect on the aggregation behavior of the proteins implicated in such diseases. Specifically, we describe the processes that generate such imbalances at the molecular level, and try to understand how they affect protein folding and localization. Overall, current knowledge suggests that microglia pro-inflammatory mediators can generate membrane damage, which may have an impact in terms of triggering or accelerating disease manifestation.
Original languageEnglish
Pages (from-to)4795-4805
JournalCellular and Molecular Life Sciences
Volume72
Issue number24
DOIs
Publication statusPublished - 1 Dec 2015

Keywords

  • Membrane
  • Microglia
  • Neurodegenerative disease
  • Neuroinflammation
  • Protein aggregation

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