Is DNA damage response ready for action anywhere?

Mariona Terradas, Marta Martín, Laia Hernández, Laura Tusell, Anna Genescà

Research output: Contribution to journalReview articleResearchpeer-review

5 Citations (Scopus)

Abstract

Organisms are continuously exposed to DNA damaging agents, consequently, cells have developed an intricate system known as the DNA damage response (DDR) in order to detect and repair DNA lesions. This response has to be rapid and accurate in order to keep genome integrity. It has been observed that the condensation state of chromatin hinders a proper DDR. However, the condensation state of chromatin is not the only barrier to DDR. In this review, we have collected data regarding the presence of DDR factors on micronuclear DNA lesions that indicate that micronuclei are almost incapable of generating an effective DDR because of defects in their nuclear envelope. Finally, considering the recent observations about the reincorporation of micronuclei to the main bulk of chromosomes, we suggest that, under certain circumstances, micronuclei carrying DNA damage might be a source of chromosome instability. © 2012 by the authors; licensee MDPI, Basel, Switzerland.
Original languageEnglish
Pages (from-to)11569-11583
JournalInternational Journal of Molecular Sciences
Volume13
Issue number9
DOIs
Publication statusPublished - 1 Sep 2012

Keywords

  • Chromosome instability
  • DSB repair
  • Micronuclei
  • NER pathway

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