In order to study the possible intermediary role of ACTH and zinc in the response of some iron metabolism related blood parameters to stress, several groups of male Wistar rats were either immobilized or given a subcutaneous injection of ACTH or zinc acetate. In immobilization and ACTH treatment, Cu and CP plasma levels as well as total ferroxidase activity rapidly decreased, returning to control or higher levels after some hours. Plasma iron showed a converse behaviour. Zinc plasma levels were lowered by stress but not ACTH. Zinc treatment antagonistically affected Cu plasmatic levels. The results suggest that ACTH actually acts as an intermediate in the ferroxidase system, plasma copper and iron response during stress.
|Publication status||Published - 1 Jan 1977|