TY - JOUR
T1 - Iron deficiency is a key determinant of health-related quality of life in patients with chronic heart failure regardless of anaemia status
AU - Comín-Colet, Josep
AU - Enjuanes, Cristina
AU - González, Gina
AU - Torrens, Ainhoa
AU - Cladellas, Mercè
AU - Meroño, Oona
AU - Ribas, Nuria
AU - Ruiz, Sonia
AU - Gómez, Miquel
AU - Verdú, José Maria
AU - Bruguera, Jordi
PY - 2013/10/1
Y1 - 2013/10/1
N2 - AimsTo evaluate the effect of iron deficiency (ID) and/or anaemia on health-related quality of life (HRQoL) in patients with chronic heart failure (CHF).Methods and resultsWe undertook a post-hoc analysis of a cohort of CHF patients in a single-centre study evaluating cognitive function. At recruitment, patients provided baseline information and completed the Minnesota Living with Heart Failure questionnaire (MLHFQ) for HRQoL (higher scores reflect worse HRQoL). At the same time, blood samples were taken for serological evaluation. ID was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. Anaemia was defined as haemoglobin ≤12 g/dL. A total of 552 CHF patients were eligible for inclusion, with an average age of 72 years and 40% in NYHA class III or IV. The MLHFQ overall summary scores were 41.0 ± 24.7 among those with ID, vs. 34.4 ± 26.4 for non-ID patients (P = 0.003), indicating worse HRQoL. When adjusted for other factors associated with HRQoL, ID was significantly associated with worse MLHFQ overall summary (P = 0.008) and physical dimension scores (P = 0.002), whereas anaemia was not (both P > 0.05). Increased levels of soluble transferrin receptor were also associated with impaired HRQoL (P ≤ 0.001). Adjusting for haemoglobin and C-reactive protein, ID was more pronounced in patients with anaemia compared with those without (P < 0.001).ConclusionIn patients with CHF, ID but not anaemia was associated with reduced HRQoL, mostly due to physical factors. © 2013 © The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology.
AB - AimsTo evaluate the effect of iron deficiency (ID) and/or anaemia on health-related quality of life (HRQoL) in patients with chronic heart failure (CHF).Methods and resultsWe undertook a post-hoc analysis of a cohort of CHF patients in a single-centre study evaluating cognitive function. At recruitment, patients provided baseline information and completed the Minnesota Living with Heart Failure questionnaire (MLHFQ) for HRQoL (higher scores reflect worse HRQoL). At the same time, blood samples were taken for serological evaluation. ID was defined as serum ferritin levels <100 ng/mL or serum ferritin <800 ng/mL with transferrin saturation <20%. Anaemia was defined as haemoglobin ≤12 g/dL. A total of 552 CHF patients were eligible for inclusion, with an average age of 72 years and 40% in NYHA class III or IV. The MLHFQ overall summary scores were 41.0 ± 24.7 among those with ID, vs. 34.4 ± 26.4 for non-ID patients (P = 0.003), indicating worse HRQoL. When adjusted for other factors associated with HRQoL, ID was significantly associated with worse MLHFQ overall summary (P = 0.008) and physical dimension scores (P = 0.002), whereas anaemia was not (both P > 0.05). Increased levels of soluble transferrin receptor were also associated with impaired HRQoL (P ≤ 0.001). Adjusting for haemoglobin and C-reactive protein, ID was more pronounced in patients with anaemia compared with those without (P < 0.001).ConclusionIn patients with CHF, ID but not anaemia was associated with reduced HRQoL, mostly due to physical factors. © 2013 © The Author 2013. Published by Oxford University Press on behalf of the European Society of Cardiology.
KW - Anaemia
KW - Health-related quality of life
KW - Iron deficiency
U2 - 10.1093/eurjhf/hft083
DO - 10.1093/eurjhf/hft083
M3 - Article
VL - 15
SP - 1164
EP - 1172
JO - European Journal of Heart Failure
JF - European Journal of Heart Failure
SN - 1388-9842
IS - 10
ER -