Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population

Miriam Umbria, Amanda Ramos, Jennifer Caner, Tomás Vega, José Eugenio Lozano, Cristina Santos, Maria Pilar Aluja

Research output: Contribution to journalArticleResearch

2 Citations (Scopus)

Abstract

© 2017 Elsevier B.V. and Mitochondria Research Society There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p = 0.001; OR = 2.379, 95% CI [1.440–3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p = 0.019; OR = 0.348, 95% CI [0.144–0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.
Original languageEnglish
Pages (from-to)1-6
JournalMitochondrion
Volume44
DOIs
Publication statusPublished - 1 Jan 2019

Keywords

  • Cardiovascular disease
  • Hypertension
  • mtDNA haplogroups
  • Myocardial infarction
  • Spain
  • Stroke

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