Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population

Miriam Umbria; Amanda Ramos; Jennifer Caner; Tomás Vega; José Eugenio Lozano; Cristina Santos; Maria Pilar Aluja

doi:10.1016/j.mito.2017.12.004

Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population

Miriam Umbria, Amanda Ramos, Jennifer Caner, Tomás Vega, José Eugenio Lozano, Cristina Santos, Maria Pilar Aluja

Research output: Contribution to journal › Article › Research

3 Citations (Scopus)

Abstract

© 2017 Elsevier B.V. and Mitochondria Research Society There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p = 0.001; OR = 2.379, 95% CI [1.440–3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p = 0.019; OR = 0.348, 95% CI [0.144–0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.

Original language	English
Pages (from-to)	1-6
Journal	Mitochondrion
Volume	44
DOIs	https://doi.org/10.1016/j.mito.2017.12.004
Publication status	Published - 1 Jan 2019

Keywords

Cardiovascular disease
Hypertension
mtDNA haplogroups
Myocardial infarction
Spain
Stroke

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.mito.2017.12.004

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title = "Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population",

abstract = "{\textcopyright} 2017 Elsevier B.V. and Mitochondria Research Society There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p = 0.001; OR = 2.379, 95% CI [1.440–3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p = 0.019; OR = 0.348, 95% CI [0.144–0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.",

keywords = "Cardiovascular disease, Hypertension, mtDNA haplogroups, Myocardial infarction, Spain, Stroke",

author = "Miriam Umbria and Amanda Ramos and Jennifer Caner and Tom{\'a}s Vega and Lozano, {Jos{\'e} Eugenio} and Cristina Santos and Aluja, {Maria Pilar}",

year = "2019",

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doi = "10.1016/j.mito.2017.12.004",

language = "English",

volume = "44",

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journal = "Mitochondrion",

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TY - JOUR

T1 - Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population

AU - Umbria, Miriam

AU - Ramos, Amanda

AU - Caner, Jennifer

AU - Vega, Tomás

AU - Lozano, José Eugenio

AU - Santos, Cristina

AU - Aluja, Maria Pilar

PY - 2019/1/1

Y1 - 2019/1/1

N2 - © 2017 Elsevier B.V. and Mitochondria Research Society There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p = 0.001; OR = 2.379, 95% CI [1.440–3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p = 0.019; OR = 0.348, 95% CI [0.144–0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.

AB - © 2017 Elsevier B.V. and Mitochondria Research Society There are strong evidences that common mitochondrial DNA (mtDNA) haplogroups may influence the pathogenesis of cardiovascular diseases (CVDs). In this matched case-control study, we investigate the association between mtDNA haplogroups and two CVDs, myocardial infarction (MI) and stroke, and classical cardiovascular risk factors. Data obtained show that haplogroup H constitute a susceptibility risk factor for MI (p = 0.001; OR = 2.379, 95% CI [1.440–3.990]). Otherwise, our data also suggest a beneficial role of haplogroup J against hypertension (p = 0.019; OR = 0.348, 95% CI [0.144–0.840]). These results may provide some guidance for predicting the genetic risk of these diseases in different human populations through the differences in energy efficiency between haplogroups.

KW - Cardiovascular disease

KW - Hypertension

KW - mtDNA haplogroups

KW - Myocardial infarction

KW - Spain

KW - Stroke

U2 - 10.1016/j.mito.2017.12.004

DO - 10.1016/j.mito.2017.12.004

M3 - Article

C2 - 29258787

SN - 1567-7249

VL - 44

SP - 1

EP - 6

JO - Mitochondrion

JF - Mitochondrion

ER -

Involvement of mitochondrial haplogroups in myocardial infarction and stroke: A case-control study in Castile and Leon (Spain) population

Abstract

Keywords

UN SDGs

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