TY - JOUR
T1 - Investigation of the influence of calibration practices on cytogenetic laboratory performance for dose estimation
AU - Trompier, François
AU - Baumann, Marion
AU - Barrios, Lleonard
AU - Gregoire, Eric
AU - Abend, Michael
AU - Ainsbury, Elizabeth
AU - Barnard, Stephen
AU - Barquinero, Joan Francesc
AU - Bautista, Juan Antonio
AU - Brzozowska, Beata
AU - Perez-Calatayud, Jose
AU - De Angelis, Cinzia
AU - Domínguez, Inmaculada
AU - Hadjidekova, Valeria
AU - Kulka, Ulrike
AU - Mateos, Juan Carlos
AU - Meschini, Roberta
AU - Monteiro Gil, Octávia
AU - Moquet, Jayne
AU - Oestreicher, Ursula
AU - Montoro Pastor, Alegria
AU - Quintens, Roel
AU - Sebastià, Natividad
AU - Sommer, Sylwester
AU - Stoyanov, Orlin
AU - Thierens, Hubert
AU - Terzoudi, Georgia
AU - Villaescusa, Juan Ignacio
AU - Vral, Anne
AU - Wojcik, Andrzej
AU - Zafiropoulos, Demetre
AU - Roy, Laurence
PY - 2017/1/2
Y1 - 2017/1/2
N2 - © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.
AB - © 2016 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. Purpose: In the frame of the QA program of RENEB, an inter-laboratory comparison (ILC) of calibration sources used in biological dosimetry was achieved to investigate the influence of calibration practices and protocols on the results of the dose estimation performance as a first step to harmonization and standardization of dosimetry and irradiation practices in the European biological dosimetry network. Materials and methods: Delivered doses by irradiation facilities used by RENEB partners were determined with EPR/alanine dosimetry system. Dosimeters were irradiated in the same conditions as blood samples. A short survey was also performed to collect the information needed for the data analysis and evaluate the diversity of practices. Results: For most of partners the deviation of delivered dose from the targeted dose remains below 10%. Deviations larger than 10% were observed for five facilities out of 21. Origins of the largest discrepancies were identified. Correction actions were evaluated as satisfactory. The re-evaluation of some ILC results for the fluorescence in situ hybridization (FISH) and premature chromosome condensation (PCC) assays has been performed leading to an improvement of the overall performances. Conclusions: This work has shown the importance of dosimetry in radiobiology studies and the needs of harmonization, standardization in irradiation and dosimetry practices and educational training for biologists using ionizing radiation.
KW - Alanine dosimetry
KW - biological dosimetry
KW - calibration
KW - inter-laboratory comparison
KW - quality assurance
U2 - 10.1080/09553002.2016.1213455
DO - 10.1080/09553002.2016.1213455
M3 - Article
SN - 0955-3002
VL - 93
SP - 118
EP - 126
JO - International Journal of Radiation Biology
JF - International Journal of Radiation Biology
IS - 1
ER -