TY - JOUR
T1 - Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle
AU - González-Prendes, R.
AU - Quintanilla, R.
AU - Amills, M.
PY - 2017/10/1
Y1 - 2017/10/1
N2 - © 2017 Stichting International Foundation for Animal Genetics A comprehensive and systematic view of the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have investigated the genetic regulation of 63 porcine genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. With this aim, we have performed an expression QTL (eQTL) scan in 104 pigs with available genotypes for the Illumina Porcine SNP60 chip and microarray measurements of gene expression in the gluteus medius muscle. Analysis of the data with gemma software revealed 13 cis- and 18 trans-eQTL modulating the expression of 19 loci. Genes regulated by eQTL participated in a wide array of lipid metabolism pathways such as the β-oxidation of fatty acids, lipid biosynthesis and lipolysis, fatty acid activation and desaturation, lipoprotein uptake, apolipoprotein assembly and cholesterol trafficking. These data provide a first picture of the genetic regulation of loci involved in porcine lipid metabolism.
AB - © 2017 Stichting International Foundation for Animal Genetics A comprehensive and systematic view of the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have investigated the genetic regulation of 63 porcine genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. With this aim, we have performed an expression QTL (eQTL) scan in 104 pigs with available genotypes for the Illumina Porcine SNP60 chip and microarray measurements of gene expression in the gluteus medius muscle. Analysis of the data with gemma software revealed 13 cis- and 18 trans-eQTL modulating the expression of 19 loci. Genes regulated by eQTL participated in a wide array of lipid metabolism pathways such as the β-oxidation of fatty acids, lipid biosynthesis and lipolysis, fatty acid activation and desaturation, lipoprotein uptake, apolipoprotein assembly and cholesterol trafficking. These data provide a first picture of the genetic regulation of loci involved in porcine lipid metabolism.
KW - association analysis
KW - gluteus medius
KW - muscle gene expression
KW - quantitative trait loci
KW - transcriptional regulation
U2 - https://doi.org/10.1111/age.12586
DO - https://doi.org/10.1111/age.12586
M3 - Article
SN - 0268-9146
VL - 48
SP - 606
EP - 610
JO - Animal Genetics
JF - Animal Genetics
ER -