Investigating the genetic regulation of the expression of 63 lipid metabolism genes in the pig skeletal muscle

R. González-Prendes, R. Quintanilla, M. Amills

Research output: Contribution to journalArticleResearchpeer-review

5 Citations (Scopus)

Abstract

© 2017 Stichting International Foundation for Animal Genetics A comprehensive and systematic view of the genetic regulation of lipid metabolism genes is still lacking in pigs. Herewith, we have investigated the genetic regulation of 63 porcine genes with crucial roles in the uptake, transport, synthesis and catabolism of lipids. With this aim, we have performed an expression QTL (eQTL) scan in 104 pigs with available genotypes for the Illumina Porcine SNP60 chip and microarray measurements of gene expression in the gluteus medius muscle. Analysis of the data with gemma software revealed 13 cis- and 18 trans-eQTL modulating the expression of 19 loci. Genes regulated by eQTL participated in a wide array of lipid metabolism pathways such as the β-oxidation of fatty acids, lipid biosynthesis and lipolysis, fatty acid activation and desaturation, lipoprotein uptake, apolipoprotein assembly and cholesterol trafficking. These data provide a first picture of the genetic regulation of loci involved in porcine lipid metabolism.
Original languageEnglish
Pages (from-to)606-610
JournalAnimal Genetics
Volume48
DOIs
Publication statusPublished - 1 Oct 2017

Keywords

  • association analysis
  • gluteus medius
  • muscle gene expression
  • quantitative trait loci
  • transcriptional regulation

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