Objective. To evaluate the effectiveness and tolerance of endovesical bacille Calmette-Guerin (BCG) after pelvic radiation therapy for bladder cancer in patients with recurrence as carcinoma in situ (CIS) and/or high-grade superficial bladder cancer. Patients and methods. In a prospective study, 13 patients were treated with weekly instillations of 81 mg BCG Connaught for 6 weeks, for CIS and/or high-grade superficial bladder carcinoma. All had been treated previously with radical radiation therapy for bladder carcinoma. Results. Five patients had no recurrences and six patients retained their bladders, within a median follow-up of 74.5 months. Five patients progressed; two underwent radical surgery and are alive after 75 months of follow-up, and three died from the disease (two were high-risk surgical patients and one had metastatic disease). Another two patients died from intercurrent disease without bladder cancer. Eight patients were alive at a mean (SD, range) follow-up of 85 (12, 65-97) months. Conclusion. Intravesical BCG is useful for controlling CIS and/or high-grade superficial bladder carcinoma in irradiated bladders and has an acceptable local tolerance; more than a third of patients were free of disease and preserved their bladders. This proportion is acceptable in patients currently scheduled for cystectomy.
|Publication status||Published - 13 Apr 1999|
- Bacille Calmette-Guerin
- Bladder neoplasm
- Carcinoma in situ