Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

Elena Martín-García; Francesco Mannara; Javier Gutiérrez-Cuesta; Lidia Sabater; Josep Dalmau; Rafael Maldonado; Francesc Graus

doi:10.1016/j.jneuroim.2013.05.003

Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

Elena Martín-García, Francesco Mannara, Javier Gutiérrez-Cuesta, Lidia Sabater, Josep Dalmau, Rafael Maldonado, Francesc Graus

Department of Psychobiology and Methodology of Health Sciences

Research output: Contribution to journal › Article › Research › peer-review

36 Citations (Scopus)

Abstract

The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. © 2013 Elsevier B.V.

Original language	English
Pages (from-to)	53-59
Journal	Journal of Neuroimmunology
Volume	261
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2013.05.003
Publication status	Published - 15 Aug 2013

Keywords

Intrathecal injection
Lambert-Eaton Myasthenic syndrome
Mouse model
P/Q-type voltage-gated calcium channel antibodies
Paraneoplastic cerebellar degeneration
Small-cell lung cancer

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.jneuroim.2013.05.003

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@article{a72c3769e1df4cbbaa33019bf9d11860,

title = "Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice",

abstract = "The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. {\textcopyright} 2013 Elsevier B.V.",

keywords = "Intrathecal injection, Lambert-Eaton Myasthenic syndrome, Mouse model, P/Q-type voltage-gated calcium channel antibodies, Paraneoplastic cerebellar degeneration, Small-cell lung cancer",

author = "Elena Mart{\'i}n-Garc{\'i}a and Francesco Mannara and Javier Guti{\'e}rrez-Cuesta and Lidia Sabater and Josep Dalmau and Rafael Maldonado and Francesc Graus",

year = "2013",

month = aug,

day = "15",

doi = "10.1016/j.jneuroim.2013.05.003",

language = "English",

volume = "261",

pages = "53--59",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice. / Martín-García, Elena; Mannara, Francesco; Gutiérrez-Cuesta, Javier et al.

In: Journal of Neuroimmunology, Vol. 261, No. 1-2, 15.08.2013, p. 53-59.

Research output: Contribution to journal › Article › Research › peer-review

TY - JOUR

T1 - Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

AU - Martín-García, Elena

AU - Mannara, Francesco

AU - Gutiérrez-Cuesta, Javier

AU - Sabater, Lidia

AU - Dalmau, Josep

AU - Maldonado, Rafael

AU - Graus, Francesc

PY - 2013/8/15

Y1 - 2013/8/15

N2 - The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. © 2013 Elsevier B.V.

AB - The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. © 2013 Elsevier B.V.

KW - Intrathecal injection

KW - Lambert-Eaton Myasthenic syndrome

KW - Mouse model

KW - P/Q-type voltage-gated calcium channel antibodies

KW - Paraneoplastic cerebellar degeneration

KW - Small-cell lung cancer

U2 - 10.1016/j.jneuroim.2013.05.003

DO - 10.1016/j.jneuroim.2013.05.003

M3 - Article

SN - 0165-5728

VL - 261

SP - 53

EP - 59

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

Abstract

Keywords

UN SDGs

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