Intrathecal injection of P/Q type voltage-gated calcium channel antibodies from paraneoplastic cerebellar degeneration cause ataxia in mice

Elena Martín-García, Francesco Mannara, Javier Gutiérrez-Cuesta, Lidia Sabater, Josep Dalmau, Rafael Maldonado, Francesc Graus

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27 Citations (Scopus)

Abstract

The role of antibodies against the P/Q type voltage-gated calcium channels (VGCC-ab) in the pathogenesis of paraneoplastic cerebellar degeneration (PCD) and lung cancer is unclear. We evaluated in mice the effect of intrathecal injection of IgG purified from serum of a patient with both PCD and Lambert-Eaton myasthenic syndrome (LEMS), and from another patient with isolated LEMS. Mice injected with PCD/LEMS IgG developed marked, reversible ataxia compared with those injected with LEMS or control IgG. These findings suggest that P/Q-type VGCC-ab may play a role in the pathogenesis of ataxia in patients with PCD and SCLC. © 2013 Elsevier B.V.
Original languageEnglish
Pages (from-to)53-59
JournalJournal of Neuroimmunology
Volume261
Issue number1-2
DOIs
Publication statusPublished - 15 Aug 2013

Keywords

  • Intrathecal injection
  • Lambert-Eaton Myasthenic syndrome
  • Mouse model
  • P/Q-type voltage-gated calcium channel antibodies
  • Paraneoplastic cerebellar degeneration
  • Small-cell lung cancer

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