Intramuscular Injections and Vaccine-Associated Poliomyelitis

Marinos C. Dalakas, Isabel Illa, Marta Leon-Monzon, R. T. Ross, Richard J. Weinberg, Aldo Rustioni, Samuel Sepkowitz, Peter M. Strebel, Roland W. Sutter, Mark A. Pallansch, Stephen L. Cochi

Research output: Other contribution

6 Citations (Scopus)

Abstract

To the Editor: The report by Strebel et al. (Feb. 23 issue)1 provides support for our ongoing work on the role of the muscle and the participation of the poliovirus receptor in the transport of the poliovirus from the muscle to the motor neurons. The poliovirus receptor, an integral membrane protein with structural characteristics of the immunoglobulin superfamily of proteins,2 is the prerequisite for infection of tissue with the poliovirus. The possible entry of the virus into the central nervous system through muscle prompted us to search for the poliovirus receptor in normal human muscle fibers and motor end plates. . .

Original languageEnglish
Number of pages3
Edition1
Volume333
DOIs
Publication statusPublished - 6 Jul 1995

Publication series

NameNew England Journal of Medicine
PublisherMassachussetts Medical Society
ISSN (Print)0028-4793

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