Intracranial self-stimulation recovers learning and memory capacity in basolateral amygdala-damaged rats

Pilar Segura-Torres, Laura Aldavert-Vera, Anna Gatell-Segura, Diego Redolar-Ripoll, Ignacio Morgado-Bernal

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)

Abstract

We studied the capacity of post-training intracranial self-stimulation (SS) to reverse or ameliorate learning and memory impairments caused by amygdala damage in rats. A first experiment showed that lesions of the basolateral amygdala (BLA) slow down acquisition of two-way active avoidance conditioning (2wAA). In a second experiment we observed that a post-training SS treatment administered immediately after each 2wAA conditioning session is able to completely reverse the disruptive effects of the BLA lesions, and the facilitative effect lasts for 10 days. A third experiment allowed us to differentiate the strong recuperative effects of the SS treatment from the slight effect caused by overtraining the same conditioning response. We concluded that SS is able to counteract the behavioral deficit induced by BLA damage, probably by activating alternative undamaged brain structures related to learning and memory, such as the hippocampus. © 2009 Elsevier Inc. All rights reserved.
Original languageEnglish
Pages (from-to)117-126
JournalNeurobiology of Learning and Memory
Volume93
DOIs
Publication statusPublished - 1 Jan 2010

Keywords

  • Active avoidance
  • Basolateral amygdala lesion
  • Intracranial self-stimulation
  • Memory modulation
  • Memory recovery
  • Rewarding brain stimulation

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