Sixteen patients with carcinoma of the penis were treated between October 1984 and January 1989 in the department of Radiation Oncology of the Hospital de la Santa Creu i Sant Pau, Barcelona, Spain. All patients were treated with interstitial implants using iridium 192 wires, associated in 1 patient with partial penectomy, in 3 patients with external radiation therapy and in 1 patient with chemotherapy. Two patients underwent inguinal node dissection and sentinel lymph node (SLN) biopsy was performed in 1 patient. The group included 8 patients with T1 tumors, 6 with T2 tumors and 2 with T3 tumors. Fourteen patients presented with no metastatic inguinal nodes (NO), and 2 patients had N1 nodes. Two patients developed local recurrence 5 and 18 months after implant: these 2 patients underwent penile amputation and are alive and well 21 and 38 months following brachytherapy. Two patients developed urethral stenosis. Two patients developed delayed metastatic nodes at 6 and 8 months after implant: 1 patient died of uncontrolled regional disease at 14 months and 1 patient is alive with regional disease at 20 months following brachytherapy. Two patients died of intercurrent disease at 6 (broncogenic carcinoma) and 25 (accident) months following interstitial radiation therapy without evidence of local disease. Overall survival rate was 79% at 4 yr and disease-free survival rate was 74% at 4 yr. Considerations regarding local and regional treatment of carcinoma of the penis are discussed in this paper.
|Journal||Bulletin du Cancer/Radiotherapie|
|Publication status||Published - 1 Jan 1991|
Guedea, F., Craven-Bartle, J., Carles, J., Isern, J., Canals, E., Germa, J. R., & Villaviciencio, U. (1991). Interstitial radiotherapy using iridium 192 wires for carcinoma of the penis. Bulletin du Cancer/Radiotherapie, 78(2), 141-147.