Intermediate dose of nonpegylated liposomal doxorubicin combination (R-CMyOP) as first line chemotherapy for frail elderly patients with aggressive lymphoma

Eva Gimeno, Blanca Sánchez-González, Alberto Álvarez-Larrán, Carmen Pedro, Eugenia Abella, Josep Comín, Silvia Saumell, Francesc García-Pallarols, Miquel Gómez, Carles Besses, Antonio Salar

Research output: Contribution to journalArticleResearchpeer-review

13 Citations (Scopus)

Abstract

Doxorubicin-containing chemotherapy is the standard regimen for elderly patients with aggressive lymphoma. However, many of them cannot receive it due to severe associated comorbidities. Toxicity and efficacy of intermediate doses of nonpegylated liposomal doxorubicin (NPLD) in modified-CHOP regimen±Rituximab were prospectively analyzed in 35 frail elderly patients (median age: 76 years) with previously untreated aggressive lymphoma with one or more severe comorbidities. NPLD at intermediate doses (30mg/m2) is effective and well tolerated in these patients. In addition, NT-proBNP levels >900ng/ml at diagnosis have demonstrated to be a good predictor for OS and PFS in this cohort of patients. © 2010 Elsevier Ltd.
Original languageEnglish
Pages (from-to)358-362
JournalLeukemia Research
Volume35
Issue number3
DOIs
Publication statusPublished - 1 Mar 2011

Keywords

  • Aggressive lymphoma
  • Chemotherapy
  • Elderly
  • Frail population
  • Nonpegylated liposomal doxorubicin

Fingerprint Dive into the research topics of 'Intermediate dose of nonpegylated liposomal doxorubicin combination (R-CMyOP) as first line chemotherapy for frail elderly patients with aggressive lymphoma'. Together they form a unique fingerprint.

  • Cite this

    Gimeno, E., Sánchez-González, B., Álvarez-Larrán, A., Pedro, C., Abella, E., Comín, J., Saumell, S., García-Pallarols, F., Gómez, M., Besses, C., & Salar, A. (2011). Intermediate dose of nonpegylated liposomal doxorubicin combination (R-CMyOP) as first line chemotherapy for frail elderly patients with aggressive lymphoma. Leukemia Research, 35(3), 358-362. https://doi.org/10.1016/j.leukres.2010.07.024