Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke

Á Chamorro*, S. Amaro, M. Vargas, V. Obach, Á Cervera, F. Torres, A. M. Planas

*Corresponding author for this work

Research output: Contribution to journalArticleResearchpeer-review

78 Citations (Scopus)

Abstract

Background and purpose: The pathophysiology of stroke-associated infection (SAI) is uncertain. The cytokine profile and peripheral white cell response were assessed in patients with or without SAI. Methods: The incidence of SAI was assessed in 110 patients with ischaemic stroke allocated antibiotic prophylaxis or placebo within 24 h of clinical onset. Peripheral white cell counts, interleukin (IL)6, tumour necrosis factor (TNF)α and IL10 were measured in plasma. Results: 17 (15%) patients developed infection and showed time-dependent increases of total white cell count, neutrophils, monocytes, lymphocytes, IL6 and IL10, whereas TNFα and the TNFα/IL10 ratio decreased. In logistic regression, IL10 (odds ratio (OR) 1.08, 95% confidence interval (CI) 1.01 to 1.16), monocyte count (OR 1.42, 95% CI 1.08 to 1.87) and National Institute for Health Stroke Survey score on admission (OR 1.17, 95% CI 1.05 to 1.31) were independent predictors of systemic infection. Conclusions: SAI is associated with stroke severity, excessive IL10-mediated response and an increased number of circulating monocytes. These results support the finding that acute ischaemic brain injury triggers a blood-borne anti-inflammatory response that decreases the antimicrobial drive of the immune system.

Original languageAmerican English
Pages (from-to)1279-1281
Number of pages3
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume77
Issue number11
DOIs
Publication statusPublished - Nov 2006

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