Interactions between dendrimers and heparin and their implications for the anti-prion activity of dendrimers

Barbara Klajnert, Michela Cangiotti, Sara Calici, Maksim Ionov, Jean Pierre Majoral, Anne Marie Caminade, Josep Cladera, Maria Bryszewska, Maria Francesca Ottaviani

Research output: Contribution to journalArticleResearchpeer-review

41 Citations (Scopus)

Abstract

Heparin is involved in the pathogenesis of prion diseases, affecting the process of fibril formation. It has been shown that whether it accelerates or inhibits fibrilogenesis depends on its concentration: prion peptide PrP 185-208 aggregates in the presence of 0.04 mg ml-1 heparin, but concentrations ten times lower or higher cause no aggregation. Polyamidoamine, polypropyleneimine and phosphorus dendrimers that previously exhibited anti-prion activity have been shown to interact with heparin. The interactions between cationic dendrimers and anionic heparin are mainly electrostatic. The present study shows that these interactions are indirectly responsible for the inhibition or enhancement of fibril formation by dendrimers. © 2009 The Royal Society of Chemistry and the Centre National de la Recherche Scientifique.
Original languageEnglish
Pages (from-to)1087-1093
JournalNew Journal of Chemistry
Volume33
Issue number5
DOIs
Publication statusPublished - 1 Dec 2009

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