Interaction Between Orexin-A and Sleep Quality in Females in Extreme Weight Conditions

Sarah Sauchelli, Susana Jiménez-Murcia, Jose C. Fernández-García, Lourdes Garrido-Sánchez, Francisco J. Tinahones, Felipe F. Casanueva, Rosa M. Baños, Cristina Botella, Ana B. Crujeiras, Rafael de la Torre, Jose M. Fernández-Real, Gema Frühbeck, Roser Granero, Francisco J. Ortega, Amaia Rodríguez, Stephan Zipfel, Katrin E. Giel, Jose M. Menchón, Fernando Fernández-Aranda

Research output: Contribution to journalArticleResearchpeer-review

7 Citations (Scopus)

Abstract

Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association. The current study examined the relationship between plasma orexin-A and sleep in obesity. Concentrations of orexin-A and sleep were evaluated in 26 obese, 40 morbid obese and 32 healthy-weight participants. The sleep monitor Actiwatch AW7 and the Pittsburgh Sleep Quality Index were used to evaluate sleep. The Symptom Checklist-90-Revised was administered to assess symptoms of psychopathology. A higher weight status was associated with elevated orexin-A levels (p =.050), greater depression, anxiety and somatization symptoms (all: p <.001), and impoverished self-reported sleep quality (p <.001). A quadratic trend was found in objective sleep time, being longest in the obese group (p =.031). Structural equation modelling showed plasma orexin-A to be related to poor total sleep quality, which in turn was associated with elevated body mass index. Our data confirm an interaction between elevated plasma orexin-A concentrations and poor sleep that contributes to fluctuations in body mass index. Copyright © 2016 John Wiley & Sons, Ltd and Eating Disorders Association.
Original languageEnglish
Pages (from-to)510-517
JournalEuropean Eating Disorders Review
Volume24
Issue number6
DOIs
Publication statusPublished - 1 Nov 2016

Keywords

  • body mass index
  • obesity
  • orexin
  • sleep

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