Interaction between chronic stress and clomipramine treatment in rats. Effects on exploratory activity, behavioral despair, and pituitary-adrenal function

C. García-Marquez, A. Armario

    Research output: Contribution to journalArticleResearchpeer-review

    39 Citations (Scopus)

    Abstract

    The interaction between the effects of chronic electrical tail shock and clomipramine (CMI) on exploratory activity, behavioral despair and pituitary-adrenal function was studied in adult male rats. Both CMI and shock administered alone significantly reduced exploratory activity in a novel environment (holeboard). Neither interaction nor additive effects were observed when the two treatments were combined. In contrast, chronic shock increased the immobility in the forced swimming test (behavioral despair) and this effect was completely prevented by concomitant CMI administration. Pituitary-adrenal function was not significantly influenced by any of the treatments. The results indicate that: (a) chronic CMI treatment prevented some but not all behavioral changes caused by chronic shock, and (b) no interaction with basal and stress levels of pituitary-adrenal hormones was observed. © 1987 Springer-Verlag.
    Original languageEnglish
    Pages (from-to)77-81
    JournalPsychopharmacology
    Volume93
    DOIs
    Publication statusPublished - 1 Sep 1987

    Keywords

    • Anti-depressant
    • Behavioral despair
    • Clomipramine
    • Pituitary-adrenal function
    • Rat

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