Integrating mechanical and biological control of cell proliferation through bioinspired multieffector materials

Joaquin Seras-Franzoso, Witold I. Tatkiewicz, Esther Vazquez, Elena García-Fruitós, Imma Ratera, Jaume Veciana, Antonio Villaverde

Research output: Contribution to journalReview articleResearchpeer-review

17 Citations (Scopus)

Abstract

© 2015 Future Medicine Ltd. In nature, cells respond to complex mechanical and biological stimuli whose understanding is required for tissue construction in regenerative medicine. However, the full replication of such bimodal effector networks is far to be reached. Engineering substrate roughness and architecture allows regulating cell adhesion, positioning, proliferation, differentiation and survival, and the external supply of soluble protein factors (mainly growth factors and hormones) has been long applied to promote growth and differentiation. Further, bioinspired scaffolds are progressively engineered as reservoirs for the in situ sustained release of soluble protein factors from functional topographies. We review here how research progresses toward the design of integrative, holistic scaffold platforms based on the exploration of individual mechanical and biological effectors and their further combination.
Original languageEnglish
Pages (from-to)873-891
JournalNanomedicine
Volume10
Issue number5
DOIs
Publication statusPublished - 1 Mar 2015

Keywords

  • adhesion proteins
  • BIOSCAFFOLDS
  • growth factor release
  • hydrogels
  • regenerative medicine
  • topography

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