Integrated optical devices for lab-on-a-chip biosensing applications

M. Carmen Estevez, Mar Alvarez, Laura M. Lechuga

    Research output: Contribution to journalReview articleResearchpeer-review

    395 Citations (Scopus)


    The application of portable, easy-to-use and highly sensitive lab-on-a-chip biosensing devices for real-time diagnosis could offer significant advantages over current analytical methods. Integrated optics-based biosensors have become the most suitable technology for lab-on-chip integration due to their ability for miniaturization, their extreme sensitivity, robustness, reliability, and their potential for multiplexing and mass production at low cost. This review provides an extended overview of the state-of-the-art in integrated photonic biosensors technology including interferometers, grating couplers, microring resonators, photonic crystals and other novel nanophotonic transducers. Particular emphasis has been placed on describing their real biosensing applications and wherever possible a comparison of the sensing performances between each type of device is included. The way towards achieving operative lab-on-a-chip platform incorporating the photonic biosensors is also reviewed. Concluding remarks regarding the future prospects and potential impact of this technology are also provided. © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
    Original languageEnglish
    Pages (from-to)463-487
    JournalLaser and Photonics Reviews
    Issue number4
    Publication statusPublished - 1 Jul 2012


    • Biofunctionalization
    • Evanescent wave detection
    • Lab-on-a-chip
    • Photonic biosensors
    • Silicon photonics.


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