Insulin-sensitizing agents: Use in pregnancy and as therapy in polycystic ovary syndrome

A. Requena, C. Salvador, R. Tur, J. Callejo, J. J. Espinós, F. Fábregues, J. Herrero, Miguel Angel Checa Vizcaino

Research output: Contribution to journalReview articleResearchpeer-review

57 Citations (Scopus)


Treatment with insulin-sensitizing agents is a relatively recent therapeutic strategy in women with polycystic ovary syndrome (PCOS) and insulin resistance. The key areas addressed in this review include PCOS and the development of type 2 diabetes mellitus and gestational diabetes, as well as the use of insulin-sensitizing agents, particularly metformin, in the management of infertility in obese and non-obese PCOS women. Treatment with metformin in PCOS women undergoing IVF and the use of metformin during gestation will be discussed. The challenge for the health care professional should be the appropriate utilization of pharmacotherapies to improve insulin sensitivity and lower circulating insulin levels resulting in beneficial changes in PCOS phenotype. Further research into the potential role of other insulin-sensitizing agents, such as pioglitazone and rosiglitazone, in the treatment of infertile women with PCOS is needed. © The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved.
Original languageEnglish
Pages (from-to)375-390
JournalHum. reprod. updat.
Issue number4
Publication statusPublished - 1 Jul 2005


  • Diabetes
  • Insulin-sensitizing agents
  • Metformin
  • Obesity
  • Polycystic ovary syndrome


Dive into the research topics of 'Insulin-sensitizing agents: Use in pregnancy and as therapy in polycystic ovary syndrome'. Together they form a unique fingerprint.

Cite this