Insulin secretion in patients with latent autoimmune diabetes (LADA): Half way between type 1 and type 2 diabetes: Action LADA 9

Marta Hernandez, Angels Mollo, Josep Ramon Marsal, Aureli Esquerda, Ismael Capel, Manel Puig-Domingo, Paolo Pozzilli, Alberto de Leiva, Didac Mauricio

Research output: Contribution to journalArticleResearchpeer-review

24 Citations (Scopus)

Abstract

© 2015 Hernandez et al.; licensee BioMed Central. Background: The study of endogenous insulin secretion may provide relevant insight into the comparison of the natural history of adult onset latent autoimmune diabetes (LADA) with types 1 and 2 diabetes mellitus. The aim of this study was to compare the results of the C-peptide response to mixed-meal stimulation in LADA patients with different disease durations and subjects with type 2 and adult-onset type 1 diabetes. Methods: Stimulated C-peptide secretion was assessed using the mixed-meal tolerance test in patients with LADA (n=32), type 1 diabetes mellitus (n=33) and type 2 diabetes mellitus (n = 30). All patients were 30 to 70 years old at disease onset. The duration of diabetes in all groups ranged from 6 months to 10 years. The recruitment strategy was predefined to include at least 10 subjects in the following 3 disease onset categories for each group: 6 to 18 months, 19 months to 5 years and 5 to 10 years. Results: At all time-points of the mixed-meal tolerance test, patients with LADA had a lower stimulated C-peptide response than the type 2 diabetes group and a higher response than the type 1 diabetes group. The same results were found when the peak or area under the C-peptide curve was measured. When the results were stratified by time since disease onset, a similar pattern of residual insulin secretory capacity was observed. Conclusions: The present study shows that the magnitude of stimulated insulin secretion in LADA is intermediate between that of type 1 and type 2 diabetes mellitus.
Original languageEnglish
Article number1
JournalBMC Endocrine Disorders
Volume15
Issue number1
DOIs
Publication statusPublished - 12 Dec 2015

Keywords

  • C-peptide
  • Insulin secretion
  • Latent autoimmune diabetes in adults
  • Type 1 diabetes mellitus
  • Type 2 diabetes mellitus

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