Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage

Alba Casellas, Cristina Mallol, Ariana Salavert, Veronica Jimenez, Miquel Garcia, Judith Agudo, Mercè Obach, Virginia Haurigot, Laia Vilà, Maria Molas, Ricardo Lage, Meritxell Morró, Estefania Casana, Jesús Ruberte, Fatima Bosch

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22 Citations (Scopus)

Abstract

© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human and animal studies have shown associations between insulin growth factor 2 (IGF2) and diabetes. Results: Overexpression of insulin growth factor 2 in β -cells leads to β -cell dysfunction and makes islets more vulnerable to β -cell damage and immune attack. Conclusion: IGF2 may play an important role in the predisposition and development of diabetes. Significance: This study unravels an unprecedented role of IGF2 on physiology of β-cells.
Original languageEnglish
Pages (from-to)16772-16785
JournalJournal of Biological Chemistry
Volume290
Issue number27
DOIs
Publication statusPublished - 3 Jul 2015

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    Casellas, A., Mallol, C., Salavert, A., Jimenez, V., Garcia, M., Agudo, J., Obach, M., Haurigot, V., Vilà, L., Molas, M., Lage, R., Morró, M., Casana, E., Ruberte, J., & Bosch, F. (2015). Insulin-like growth factor 2 overexpression induces β-Cell dysfunction and increases beta-cell susceptibility to damage. Journal of Biological Chemistry, 290(27), 16772-16785. https://doi.org/10.1074/jbc.M115.642041