Abstract
© 2015 by The American Society for Biochemistry and Molecular Biology, Inc. Background: Human and animal studies have shown associations between insulin growth factor 2 (IGF2) and diabetes. Results: Overexpression of insulin growth factor 2 in β -cells leads to β -cell dysfunction and makes islets more vulnerable to β -cell damage and immune attack. Conclusion: IGF2 may play an important role in the predisposition and development of diabetes. Significance: This study unravels an unprecedented role of IGF2 on physiology of β-cells.
Original language | English |
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Pages (from-to) | 16772-16785 |
Journal | Journal of Biological Chemistry |
Volume | 290 |
Issue number | 27 |
DOIs | |
Publication status | Published - 3 Jul 2015 |