Inhibitory effects of neuropeptide Y (NPY) on CRF and stress-induced cecal motor response in rats

M. Jiménez, L. Buéno

    Research output: Contribution to journalArticleResearchpeer-review

    32 Citations (Scopus)

    Abstract

    The effects of NPY on CRF and stress-stimulated cecal motility were investigated by electromyography in rats. Intracerebroventricular (ICV) injection of NPY at 300 ng/kg significantly reduced the frequency of spike burst during the first 15 minutes after its administration while no effects was observed at a lower dose (150 ng/kg). Exposure to mental stress (MS) increased significantly (p<0.01) during 45 minutes, the frequency of cecal spike bursts. NPY (300 ng/kg) injected ICV, 30 minutes prior to MS periods abolished the excitatory effects induced by stress. The frequency of cecal spike bursts was also increased during the first 15-minutes following ICV injection of CRF (300 ng/kg). Prior (5 min) ICV administration of NPY (150 ng/kg) abolished the stimulatory effect of CRF on cecal motility. It is concluded that central administration of NPY suppresses the stress-induced cecal motor response probably by inhibiting the pathways involved in CRF mediation of these effects. © 1990.
    Original languageEnglish
    Pages (from-to)205-211
    JournalLife Sciences
    Volume47
    DOIs
    Publication statusPublished - 1 Jan 1990

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