Inhibition of MAO by substituted tryptamine analogues.

D. Balsa, E. Fernandez-Alvarez, K. F. Tipton, M. Unzeta

Research output: Contribution to journalArticleResearchpeer-review

15 Citations (Scopus)


Three different acetylenic analogues of tryptamine, in which the side chain is attached at the 2 position of the heterocyclic ring, were studied as inhibitors of MAO-A and MAO-B. IC50 values were determined after 30 min preincubation of the enzyme and inhibitor, at 37 degrees C before assay. Irreversibility and time-dependence of the inhibition were also established in each case. The kinetic parameters defining non-covalent complex formation and covalent adduct formation were calculated for the mechanism-based inhibition of both MAO-A and MAO-B by these compounds.
Original languageEnglish
Pages (from-to)103-105
JournalJournal of neural transmission. Supplementum
Issue number32
Publication statusPublished - 1 Jan 1990

Fingerprint Dive into the research topics of 'Inhibition of MAO by substituted tryptamine analogues.'. Together they form a unique fingerprint.

Cite this