Inhibition of delta-like ligand 4 decreases Th1/Th17 response in a mouse model of multiple sclerosis

Herena Eixarch, M. José Mansilla, Carme Costa, Steve L. Kunkel, Xavier Montalban, Núria Godessart, Carmen Espejo

Research output: Contribution to journalArticleResearchpeer-review

14 Citations (Scopus)

Abstract

Notch is a family of receptors involved in the differentiation of several tissues, including the central nervous system and the immune system. One of the Notch ligands, delta-like 4 (Dll4), has been implicated in the differentiation of Th1 cells and the development of Th17 responses, which are involved in the pathogenesis of experimental autoimmune encephalomyelitis (EAE) and multiple sclerosis. Our results show that a single administration of an anti-Dll4 antibody is not enough to avoid the development of EAE or to ameliorate the already established clinical signs, despite the treatment reduces the proliferative T cell responses and decreases Th1/Th17 immune responses. © 2013 Elsevier Ireland Ltd.
Original languageEnglish
Pages (from-to)161-166
JournalNeuroscience Letters
Volume541
DOIs
Publication statusPublished - 29 Apr 2013

Keywords

  • Dll4
  • EAE
  • Multiple sclerosis
  • Notch
  • Th17

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