Inhibition of CI857-controlled recombinant gene expression in Escherichia coli at very low concentrations of glucose

P. Vila, A. Villaverde

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5 Citations (Scopus)

Abstract

The effects of glucose on biomass and temperature-mediated recombinant gene expression has been studied in Escherichia coli batch cultures. Glucose, above 2 g/L, has inhibitory effects on aerobic cell growth and specially on gene expression. Although lower concentrations have no influences on biomass, a tenuous, but still remarkable concentration-dependent reduction of gene expression levels was observed even at about 0.1 g/L. © 1993 Chapman & Hall.
Original languageEnglish
Pages (from-to)549-552
JournalBiotechnology Letters
Volume15
Issue number6
DOIs
Publication statusPublished - 1 Jun 1993

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