Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort

Jaume Alijotas-Reig, Raquel Ferrer-Oliveras, Enrique Esteve-Valverde, Amelia Ruffatti, Angela Tincani, Elmina Lefkou, Maria Tiziana Bertero, Gerard Espinosa, Emmanuel Coloma, Sara de Carolis, Patrizia Rovere-Querini, Valentina Canti, Elisa Picardo, Micaela Fredi, Arsene Mekinian, Anna Kuzenko, Anna Ruano, Teresa del Ross, Taisiia Melnychuk, Krista LundelinElisa Llurba, Ricard Cervera, Bettina Toth, Luis Saez-Comet, Katharina Bremme, Karoline Mayer-Pickel, Antonio Gil-Aguado

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Abstract

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd Aim: To analyse the prevalence and effects of inherited thrombophilic disorders (ITD) on maternal–foetal outcomes in cases of antiphospholipid antibody related to obstetric complications. Methods: Women with obstetric complaints who tested positive for aPL and with inherited thrombophilia were prospectively and retrospectively included. Results: ITD data were available in 208 of 338: 147 had obstetric antiphospholipid syndrome (OAPS) and 61 aPL-related obstetric morbidity (OMAPS). 24.1% had ITD. Laboratory categories I and IIa were more related to OAPS-ITD and IIb and IIc to OMAPS-ITD. No significant differences in obstetric complaints were observed. Regarding ITD carriers, treatment rates were higher in OAPS than in OMAPS for LMWH and LDA plus LMWH (P=.002). Conclusion: Cases with aPL-related OAPS/OMAPS showed no differences in maternal–foetal outcomes regardless of the presence of one ITD. Maternal thrombotic risk was low, with ITD-positive cases included. Registry data concur with Sydney criteria, whereby aPL-ITD-positive patients are classified as having antiphospholipid syndrome.
Original languageEnglish
Pages (from-to)164-171
JournalAmerican Journal of Reproductive Immunology
Volume76
Issue number2
DOIs
Publication statusPublished - 1 Aug 2016

Keywords

  • antiphospholipid antibody
  • inherited thrombophilia
  • obstetric outcome
  • thrombosis
  • treatment

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    Alijotas-Reig, J., Ferrer-Oliveras, R., Esteve-Valverde, E., Ruffatti, A., Tincani, A., Lefkou, E., Bertero, M. T., Espinosa, G., Coloma, E., de Carolis, S., Rovere-Querini, P., Canti, V., Picardo, E., Fredi, M., Mekinian, A., Kuzenko, A., Ruano, A., del Ross, T., Melnychuk, T., ... Gil-Aguado, A. (2016). Inherited thrombophilia in women with poor aPL-related obstetric history: prevalence and outcomes. Survey of 208 cases from the European Registry on Obstetric Antiphospholipid Syndrome cohort. American Journal of Reproductive Immunology, 76(2), 164-171. https://doi.org/10.1111/aji.12534