Influence of the type of pegylated interferon on the onset of depressive and neuropsychiatric symptoms in HIV-HCV coinfected patients

C. R. Fumaz, J. A. Muñoz-Moreno, A. L. Ballesteros, R. Paredes, M. J. Ferrer, A. Salas, D. Fuster, E. Masmitjà, N. Pérez-Álvarez, G. Gómez, C. Tural, B. Clotet

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Abstract

This is a prospective observational comparative 48-week study to assess the impact of the different types of Peg-IFN on depressive and neuropsychiatric symptoms during treatment in HIV-HCV coinfected patients. Thirty-one patients treated with Peg-IFN α-2b 1.5μg/kg/w plus ribavirine (RBV) (Peg-IFN α-2b Group) and 32 patients receiving Peg-IFN α-2a 180μg/w plus RBV (Peg-IFN α-2a Group) were included. Depressive and neuropsychiatric symptoms, quality of life and adherence were assessed. Fifteen subjects (23%) discontinued therapy (p = 0.3, between groups). Overall, 37 patients presented mild to moderate depressive symptoms, 9 moderate to severe and 3 severe, without differences between groups. Patients in Peg-IFN α-2b reported higher fatigue and dizziness at weeks 12 (p < 0.05) and 24 (p < 0.05), and irritability and memory loss at week 24 (p < 0.05) with respect to Peg-IFN α-2a Group. At week 12, role functioning, general health perception, vitality, emotional role, mental health and the summary areas of physical health and mental health were lower in Peg-IFN α-2b Group (p < 0.05). The same was observed in physical functioning (p = 0.05) and role functioning, general health perception, emotional role and mental health (p < 0.001) at week 24. Three months after finishing treatment, no patient had depressive or neuropsychiatric symptoms, and quality of life improved. Antiretroviral adherence was low but adherence to anti-HCV therapy remained high in both groups. According to our data, Peg-IFN α-2a and Peg-IFN α-2b exert a similar impact on the overall rate of depressive symptoms, although patients treated with Peg-IFN α-2a experience less fatigue and fewer neuropsychiatric symptoms and a lower impairment in their physical and mental quality of life. © 2007 Taylor & Francis.
Original languageEnglish
Pages (from-to)138-145
JournalAIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
Volume19
Issue number1
DOIs
Publication statusPublished - 1 Jan 2007

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