Influence of extracellular calcium in the effects of dibekacin and diltiazem on indirectly elicited tetanic responses in the rat phrenic-hemidiaphragm preparation

J. E. Baños, F. Bosch, A. Badia

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium. © 1990.
    Original languageEnglish
    Pages (from-to)521-525
    JournalGeneral Pharmacology
    Volume21
    DOIs
    Publication statusPublished - 1 Jan 1990

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