Abstract
1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium. © 1990.
Original language | English |
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Pages (from-to) | 521-525 |
Journal | General Pharmacology |
Volume | 21 |
DOIs | |
Publication status | Published - 1 Jan 1990 |