Influence of extracellular calcium in the effects of dibekacin and diltiazem on indirectly elicited tetanic responses in the rat phrenic-hemidiaphragm preparation

J. E. Baños; F. Bosch; A. Badia

doi:https://doi.org/10.1016/0306-3623(90)90708-T

Influence of extracellular calcium in the effects of dibekacin and diltiazem on indirectly elicited tetanic responses in the rat phrenic-hemidiaphragm preparation

J. E. Baños, F. Bosch, A. Badia

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Abstract

1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium. © 1990.

Original language	English
Pages (from-to)	521-525
Journal	General Pharmacology
Volume	21
DOIs	https://doi.org/10.1016/0306-3623(90)90708-T
Publication status	Published - 1 Jan 1990

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title = "Influence of extracellular calcium in the effects of dibekacin and diltiazem on indirectly elicited tetanic responses in the rat phrenic-hemidiaphragm preparation",

abstract = "1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium. {\textcopyright} 1990.",

author = "Ba{\~n}os, {J. E.} and F. Bosch and A. Badia",

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T1 - Influence of extracellular calcium in the effects of dibekacin and diltiazem on indirectly elicited tetanic responses in the rat phrenic-hemidiaphragm preparation

AU - Baños, J. E.

AU - Bosch, F.

AU - Badia, A.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - 1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium. © 1990.

AB - 1. Dibekacin (70 μM-3 mM) produced a decrease of peak tetanic tension in a concentration-dependent manner and this effect was dependent on extracellular calcium (0.3-2.5 mM Ca2+). Only minimal fade was observed and it was not related with extracellular calcium concentrations. 2. Diltiazem (30-300 μM) decreased peak tetanic tension and produced tetanic fade. Both effects were independent of extracellular calcium, although a significant potentiation was observed at 0.3 mM calcium. 3. It is concluded that tetanic parameters are related differently to extracellular calcium. © 1990.

U2 - https://doi.org/10.1016/0306-3623(90)90708-T

DO - https://doi.org/10.1016/0306-3623(90)90708-T

M3 - Article

VL - 21

SP - 521

EP - 525

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