Influence of early neurological complications on clinical outcome following lung transplant

Josep Gamez, Maria Salvado, Alejandro Martinez-De La Ossa, Maria Deu, Laura Romero, Antonio Roman, Judith Sacanell, Cesar Laborda, Isabel Rochera, Miriam Nadal, Francesc Carmona, Estevo Santamarina, Nuria Raguer, Merce Canela, Joan Solé

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10 Citations (Scopus)


© 2017 Gamez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Background Neurological complications after lung transplantation are common. The full spectrum of neurological complications and their impact on clinical outcomes has not been extensively studied. Methods We investigated the neurological incidence of complications, categorized according to whether they affected the central, peripheral or autonomic nervous systems, in a series of 109 patients undergoing lung transplantation at our center between January 1 2013 and December 31 2014. Results Fifty-one patients (46.8%) presented at least one neurological complication. Critical illness polyneuropathy-myopathy (31 cases) and phrenic nerve injury (26 cases) were the two most prevalent complications. These two neuromuscular complications lengthened hospital stays by a median period of 35.5 and 32.5 days respectively. However, neurological complications did not affect patients' survival. Conclusions The real incidence of neurological complications among lung transplant recipients is probably underestimated. They usually appear in the first two months after surgery. Despite not affecting mortality, they do affect the mean length of hospital stay, and especially the time spent in the Intensive Care Unit. We found no risk factor for neurological complications except for long operating times, ischemic time and need for transfusion. It is necessary to develop programs for the prevention and early recognition of these complications, and the prevention of their precipitant and risk factors.
Original languageEnglish
Article numbere0174092
JournalPloS one
Issue number3
Publication statusPublished - 1 Mar 2017


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