Influence of chronic illnesses and underlying risk conditions on the incidence of pneumococcal pneumonia in older adults

Angel Vila-Corcoles, Carlos Aguirre-Chavarria, Olga Ochoa-Gondar, Cinta de Diego, Teresa Rodriguez-Blanco, Frederic Gomez, Xavier Raga, Luis Barnes, Ramon Magarolas, Leonardo Esteban

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    16 Citations (Scopus)

    Abstract

    © 2015, Springer-Verlag Berlin Heidelberg. Objective: To investigate hospitalizations from pneumococcal pneumonia in older adults with specific underlying chronic conditions, evaluating the influence of these conditions in developing pneumonia. Methods: Population-based cohort study involving 27,204 individuals ≥60 years old in Southern Catalonia, Spain. All cases of hospitalization from pneumococcal pneumonia (bacteremic and nonbacteremic) were collected since 01/12/2008 until 30/11/2011. Cox regression was used to calculate hazards ratio (HR) and estimate the association between baseline conditions and the risk of developing pneumococcal pneumonia. Results: Maximum incidences (per 1000 person-years) appeared among patients with history of prior pneumonia (14.6), nursing home residents (12.8), persons with immunodeficiency/asplenia (7.7) and patients with chronic pulmonary disease (7.6). In multivariable analysis, age (HR: 1.05), nursing home residence (HR: 4.59), history of prior pneumonia (HR: 3.58), stroke (HR: 2.50), chronic heart disease (HR: 1.53), chronic pulmonary disease (HR: 4.09), diabetes mellitus (HR: 1.66), smoking (HR: 1.69) and immunosuppressive medication (HR: 1.87) appeared significantly associated with an increased risk of pneumococcal pneumonia. Conclusion: Our data support that nursing home residence, chronic pulmonary disease and immunocompromising conditions are the underlying conditions most strongly associated with an increasing risk of pneumococcal pneumonia in older adults. This data underline the need for better prevention strategies among these persons.
    Original languageEnglish
    Pages (from-to)699-706
    JournalInfection
    Volume43
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 2015

    Keywords

    • Incidence
    • Pneumococcal pneumonia
    • Risk factors
    • Streptococcus pneumoniae

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