Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior

R. M. Escorihuela; A. Fernández-Teruel; F. J. Núñez; A. Zapata; A. Tobeña

doi:10.1007/BF02801985

Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior

R. M. Escorihuela, A. Fernández-Teruel, F. J. Núñez, A. Zapata, A. Tobeña

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Abstract

The present study shows that postnatal "consistent" handling (CH) of rats had long-lasting improving effects on coping with an stressful task (i.e. two-way active avoidance), and that such effects were partially prevented by acute Ro 15-1788 (antagonist of benzodiazepine receptor-BZR; 5 mg/kg) administration. Long-lasting detrimental effects in the same task were also observed in rats which received postnatal "inconsistent" handling (INCH), effects that were slightly increased by acute Ro 15-1788 treatment. Finally, Ro 15-1788 tended to increase avoidance acquisition in non-handled (NH) animals. The observed effects of Ro 15-1788 could be partially attributed to a differential modulation of the process of avoidance acquisition depending on postnatal treatments producing different levels of emotionality. © 1992 Springer-Verlag.

Original language	English
Pages (from-to)	282-284
Journal	Psychopharmacology
Volume	106
Issue number	2
DOIs	https://doi.org/10.1007/BF02801985
Publication status	Published - 1 Jun 1992

Keywords

Coping behavior
Emotional reactivity
Handling
Postnatal experience
Rat
Ro 15-1788

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10.1007/BF02801985

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title = "Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior",

abstract = "The present study shows that postnatal {"}consistent{"} handling (CH) of rats had long-lasting improving effects on coping with an stressful task (i.e. two-way active avoidance), and that such effects were partially prevented by acute Ro 15-1788 (antagonist of benzodiazepine receptor-BZR; 5 mg/kg) administration. Long-lasting detrimental effects in the same task were also observed in rats which received postnatal {"}inconsistent{"} handling (INCH), effects that were slightly increased by acute Ro 15-1788 treatment. Finally, Ro 15-1788 tended to increase avoidance acquisition in non-handled (NH) animals. The observed effects of Ro 15-1788 could be partially attributed to a differential modulation of the process of avoidance acquisition depending on postnatal treatments producing different levels of emotionality. {\textcopyright} 1992 Springer-Verlag.",

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T1 - Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior

AU - Escorihuela, R. M.

AU - Fernández-Teruel, A.

AU - Núñez, F. J.

AU - Zapata, A.

AU - Tobeña, A.

PY - 1992/6/1

Y1 - 1992/6/1

N2 - The present study shows that postnatal "consistent" handling (CH) of rats had long-lasting improving effects on coping with an stressful task (i.e. two-way active avoidance), and that such effects were partially prevented by acute Ro 15-1788 (antagonist of benzodiazepine receptor-BZR; 5 mg/kg) administration. Long-lasting detrimental effects in the same task were also observed in rats which received postnatal "inconsistent" handling (INCH), effects that were slightly increased by acute Ro 15-1788 treatment. Finally, Ro 15-1788 tended to increase avoidance acquisition in non-handled (NH) animals. The observed effects of Ro 15-1788 could be partially attributed to a differential modulation of the process of avoidance acquisition depending on postnatal treatments producing different levels of emotionality. © 1992 Springer-Verlag.

AB - The present study shows that postnatal "consistent" handling (CH) of rats had long-lasting improving effects on coping with an stressful task (i.e. two-way active avoidance), and that such effects were partially prevented by acute Ro 15-1788 (antagonist of benzodiazepine receptor-BZR; 5 mg/kg) administration. Long-lasting detrimental effects in the same task were also observed in rats which received postnatal "inconsistent" handling (INCH), effects that were slightly increased by acute Ro 15-1788 treatment. Finally, Ro 15-1788 tended to increase avoidance acquisition in non-handled (NH) animals. The observed effects of Ro 15-1788 could be partially attributed to a differential modulation of the process of avoidance acquisition depending on postnatal treatments producing different levels of emotionality. © 1992 Springer-Verlag.

KW - Coping behavior

KW - Emotional reactivity

KW - Handling

KW - Postnatal experience

KW - Rat

KW - Ro 15-1788

U2 - 10.1007/BF02801985

DO - 10.1007/BF02801985

M3 - Article

SN - 0033-3158

VL - 106

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JO - Psychopharmacology

JF - Psychopharmacology

IS - 2

ER -

Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior

Abstract

Keywords

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