Infantile stimulation and the role of the benzodiazepine receptor system in adult acquisition of two-way avoidance behavior

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Abstract

The present study shows that postnatal "consistent" handling (CH) of rats had long-lasting improving effects on coping with an stressful task (i.e. two-way active avoidance), and that such effects were partially prevented by acute Ro 15-1788 (antagonist of benzodiazepine receptor-BZR; 5 mg/kg) administration. Long-lasting detrimental effects in the same task were also observed in rats which received postnatal "inconsistent" handling (INCH), effects that were slightly increased by acute Ro 15-1788 treatment. Finally, Ro 15-1788 tended to increase avoidance acquisition in non-handled (NH) animals. The observed effects of Ro 15-1788 could be partially attributed to a differential modulation of the process of avoidance acquisition depending on postnatal treatments producing different levels of emotionality. © 1992 Springer-Verlag.
Original languageEnglish
Pages (from-to)282-284
JournalPsychopharmacology
Volume106
Issue number2
DOIs
Publication statusPublished - 1 Jun 1992

Keywords

  • Coping behavior
  • Emotional reactivity
  • Handling
  • Postnatal experience
  • Rat
  • Ro 15-1788

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