Induction of the SOS response by bacteriophage lytic development in Salmonella enterica

Susana Campoy; Anna Hervàs; Núria Busquets; Ivan Erill; Laura Teixidó; Jordi Barbé

doi:10.1016/j.virol.2006.04.001

Induction of the SOS response by bacteriophage lytic development in Salmonella enterica

Susana Campoy, Anna Hervàs, Núria Busquets, Ivan Erill, Laura Teixidó, Jordi Barbé

Department of Genetics and Microbiology

Research output: Contribution to journal › Article › Research › peer-review

30 Citations (Scopus)

Abstract

Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression of the kil gene also promotes the S. enterica SOS network induction. Furthermore, S. enterica Gifsy prophages are induced following the infection with SE1 and P22 lytic derivatives. The observed data reveal a hitherto unknown SOS system-mediated fail-safe mechanism of resident prophages against infection with heteroimmune lytic bacteriophages and suggest a novel role for the kil family of proteins. © 2006 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	360-367
Journal	Virology
Volume	351
DOIs	https://doi.org/10.1016/j.virol.2006.04.001
Publication status	Published - 1 Aug 2006

Keywords

Bacteriophage lytic cycle
Kil gene
Resident prophages
SOS system
Salmonella enterica

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10.1016/j.virol.2006.04.001

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title = "Induction of the SOS response by bacteriophage lytic development in Salmonella enterica",

abstract = "Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression of the kil gene also promotes the S. enterica SOS network induction. Furthermore, S. enterica Gifsy prophages are induced following the infection with SE1 and P22 lytic derivatives. The observed data reveal a hitherto unknown SOS system-mediated fail-safe mechanism of resident prophages against infection with heteroimmune lytic bacteriophages and suggest a novel role for the kil family of proteins. {\textcopyright} 2006 Elsevier Inc. All rights reserved.",

keywords = "Bacteriophage lytic cycle, Kil gene, Resident prophages, SOS system, Salmonella enterica",

author = "Susana Campoy and Anna Herv{\`a}s and N{\'u}ria Busquets and Ivan Erill and Laura Teixid{\'o} and Jordi Barb{\'e}",

year = "2006",

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doi = "10.1016/j.virol.2006.04.001",

language = "English",

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TY - JOUR

T1 - Induction of the SOS response by bacteriophage lytic development in Salmonella enterica

AU - Campoy, Susana

AU - Hervàs, Anna

AU - Busquets, Núria

AU - Erill, Ivan

AU - Teixidó, Laura

AU - Barbé, Jordi

PY - 2006/8/1

Y1 - 2006/8/1

N2 - Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression of the kil gene also promotes the S. enterica SOS network induction. Furthermore, S. enterica Gifsy prophages are induced following the infection with SE1 and P22 lytic derivatives. The observed data reveal a hitherto unknown SOS system-mediated fail-safe mechanism of resident prophages against infection with heteroimmune lytic bacteriophages and suggest a novel role for the kil family of proteins. © 2006 Elsevier Inc. All rights reserved.

AB - Infection of Salmonella enterica with lytic mutants of either P22 or SE1 bacteriophages triggers the expression of its DNA damage-inducible SOS response through a lexA-dependent pathway. This induction of the SOS system strictly requires the presence of the bacteriophage kil gene. Accordingly, plasmid overexpression of the kil gene also promotes the S. enterica SOS network induction. Furthermore, S. enterica Gifsy prophages are induced following the infection with SE1 and P22 lytic derivatives. The observed data reveal a hitherto unknown SOS system-mediated fail-safe mechanism of resident prophages against infection with heteroimmune lytic bacteriophages and suggest a novel role for the kil family of proteins. © 2006 Elsevier Inc. All rights reserved.

KW - Bacteriophage lytic cycle

KW - Kil gene

KW - Resident prophages

KW - SOS system

KW - Salmonella enterica

U2 - 10.1016/j.virol.2006.04.001

DO - 10.1016/j.virol.2006.04.001

M3 - Article

SN - 0042-6822

VL - 351

SP - 360

EP - 367

JO - Virology

JF - Virology

ER -

Induction of the SOS response by bacteriophage lytic development in Salmonella enterica

Abstract

Keywords

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