Induction of mitotic micronuclei by the pyrethroid insecticide fenvalerate in cultured human lymphocytes

J. Surralles, E. Carboneil, M. Puig, N. Xamena, A. Creus, R. Marcos

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38 Citations (Scopus)

Abstract

The pyrethroid insecticide fenvalerate was tested for its ability to induce mitotic micronuclei in cytokinesis-block cells of cultured human peripheral blood lymphocytes at concentrations ranging from 10 to 50 μg ml. We observed that fenvalerate induces a significant increase in the frequency of micronuclei, indicating clastogenic and/or aneugenic activity. Our results complement previous data on the genotoxicity of this compound in human lymphocytes. © 1990.
Original languageEnglish
Pages (from-to)151-155
JournalToxicology Letters
Volume54
Issue number2-3
DOIs
Publication statusPublished - 1 Jan 1990

Keywords

  • Fenvalerate
  • Human lymphocytes
  • Micronuclei

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