Induction of incomplete and complex chromosome aberrations by 30 kVp X rays.

Marta Mestres; Leila Benkhaled; María Rosa Caballín; Leonardo Barrios; Montserrat Ribas; Joan Francesc Barquinero

doi:10.1667/RR2183.1

Induction of incomplete and complex chromosome aberrations by 30 kVp X rays.

Marta Mestres, Leila Benkhaled, María Rosa Caballín, Leonardo Barrios, Montserrat Ribas, Joan Francesc Barquinero^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Research › peer-review

8 Citations (Scopus)

Abstract

X rays of 26-30 kVp are routinely used for mammography screening. For radioprotection purposes, a quality factor (Q) of 1 is assumed for all photon energies, but it is thought that the relative biological effectiveness (RBE) increases as the photon energy decreases. The analysis of radiation-induced chromosome aberrations is one of the most widely used methods to study the interaction between radiation and DNA. Here we present a FISH study on metaphases from peripheral blood samples irradiated with three different X-ray energies (30, 80 and 120 kVp). The study comprises two FISH approaches: one using pantelomeric and pancentromeric probes to evaluate the induction of incomplete chromosome aberrations and the other using mFISH to evaluate the induction of complex chromosome aberrations. The results indicate that exposure to 30 kVp X rays resulted in a modest increase in the induction of incomplete elements and complex aberrations compared to 80 and 120 kVp X rays.

Original language	English
Pages (from-to)	201-207
Journal	Radiation Research
Volume	175
Issue number	2
DOIs	https://doi.org/10.1667/RR2183.1
Publication status	Published - 1 Feb 2011

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title = "Induction of incomplete and complex chromosome aberrations by 30 kVp X rays.",

abstract = "X rays of 26-30 kVp are routinely used for mammography screening. For radioprotection purposes, a quality factor (Q) of 1 is assumed for all photon energies, but it is thought that the relative biological effectiveness (RBE) increases as the photon energy decreases. The analysis of radiation-induced chromosome aberrations is one of the most widely used methods to study the interaction between radiation and DNA. Here we present a FISH study on metaphases from peripheral blood samples irradiated with three different X-ray energies (30, 80 and 120 kVp). The study comprises two FISH approaches: one using pantelomeric and pancentromeric probes to evaluate the induction of incomplete chromosome aberrations and the other using mFISH to evaluate the induction of complex chromosome aberrations. The results indicate that exposure to 30 kVp X rays resulted in a modest increase in the induction of incomplete elements and complex aberrations compared to 80 and 120 kVp X rays.",

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T1 - Induction of incomplete and complex chromosome aberrations by 30 kVp X rays.

AU - Mestres, Marta

AU - Benkhaled, Leila

AU - Caballín, María Rosa

AU - Barrios, Leonardo

AU - Ribas, Montserrat

AU - Barquinero, Joan Francesc

PY - 2011/2/1

Y1 - 2011/2/1

N2 - X rays of 26-30 kVp are routinely used for mammography screening. For radioprotection purposes, a quality factor (Q) of 1 is assumed for all photon energies, but it is thought that the relative biological effectiveness (RBE) increases as the photon energy decreases. The analysis of radiation-induced chromosome aberrations is one of the most widely used methods to study the interaction between radiation and DNA. Here we present a FISH study on metaphases from peripheral blood samples irradiated with three different X-ray energies (30, 80 and 120 kVp). The study comprises two FISH approaches: one using pantelomeric and pancentromeric probes to evaluate the induction of incomplete chromosome aberrations and the other using mFISH to evaluate the induction of complex chromosome aberrations. The results indicate that exposure to 30 kVp X rays resulted in a modest increase in the induction of incomplete elements and complex aberrations compared to 80 and 120 kVp X rays.

AB - X rays of 26-30 kVp are routinely used for mammography screening. For radioprotection purposes, a quality factor (Q) of 1 is assumed for all photon energies, but it is thought that the relative biological effectiveness (RBE) increases as the photon energy decreases. The analysis of radiation-induced chromosome aberrations is one of the most widely used methods to study the interaction between radiation and DNA. Here we present a FISH study on metaphases from peripheral blood samples irradiated with three different X-ray energies (30, 80 and 120 kVp). The study comprises two FISH approaches: one using pantelomeric and pancentromeric probes to evaluate the induction of incomplete chromosome aberrations and the other using mFISH to evaluate the induction of complex chromosome aberrations. The results indicate that exposure to 30 kVp X rays resulted in a modest increase in the induction of incomplete elements and complex aberrations compared to 80 and 120 kVp X rays.

U2 - 10.1667/RR2183.1

DO - 10.1667/RR2183.1

M3 - Article

SN - 1938-5404

VL - 175

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JO - Radiation Research

JF - Radiation Research

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ER -

Induction of incomplete and complex chromosome aberrations by 30 kVp X rays.

Abstract

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