Induction of c-Fos expression by electrical stimulation of the nucleus basalis magnocellularis

Research output: Contribution to journalArticleResearchpeer-review

8 Citations (Scopus)

Abstract

The present study examined the expression of the immediate-early gene c-fos in different brain regions following a single 20-min session of unilateral electrical stimulation of the nucleus basalis magnocellularis (NBM). Current findings confirm that NBM stimulation provides specific activation of several cortical and subcortical regions closely related to the NBM and involved in learning and memory processes, such as the cingulate, parietal, piriform and perirhinal cortices, dorsal subiculum, and the parafascicular, central lateral and central medial nuclei of the thalamus. In contrast, NBM stimulation did not increase c-Fos expression in some expected areas that receive direct NBM projections such as the entorhinal cortex or amygdala nuclei. Results are discussed in terms of the possibility that NBM electrical stimulation facilitates learning by inducing neural changes related to transcription factors such as c-Fos. © 2008 Elsevier Ireland Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)137-141
JournalNeuroscience Letters
Volume449
DOIs
Publication statusPublished - 9 Jan 2009

Keywords

  • Basal forebrain
  • Electrical stimulation
  • Immediate-early gene expression
  • Learning and memory
  • Nucleus basalis magnocellularis
  • Rat

Fingerprint

Dive into the research topics of 'Induction of c-Fos expression by electrical stimulation of the nucleus basalis magnocellularis'. Together they form a unique fingerprint.

Cite this