Indications of PCSK9 inhibitors in clinical practice. Recommendations of the Spanish Sociey of Arteriosclerosis (SEA), 2019

Juan Francisco Ascaso, Fernando Civeira, Carlos Guijarro, José López Miranda, Luis Masana, José María Mostaza, Juan Pedro-Botet, Xavier Pintó, Pedro Valdivielso

Research output: Contribution to journalArticleResearch

8 Citations (Scopus)

Abstract

© 2019 The Authors A group of experts convened by the Spanish Society of Arteriosclerosis (SEA) has been in charge of updating the SEA document on the indications of PCSK9 inhibitors (PCSK9i) in clinical practice that was published in 2016. This update is justified by the fact that the data from clinical trials carried out on a large scale with PCSK9i have shown that in addition to their high potency to lower atherogenic cholesterol, they reduce the risk of atherosclerotic cardiovascular disease, both in patients with stable disease, and with recent disease, and with a high degree of security. This update provides the recommendations and level of evidence for the prescription of iPCSK9 in patients with homozygous and heterozygous familial hypercholesterolemia, with atherosclerotic cardiovascular disease, and in primary prevention in patients with very high cardiovascular risk. These recommendations have been established taking into account the concentration of LDL-C, the clinical situation of the patient, the additional risk factors and the cost-effectiveness of their use.
Original languageEnglish
Pages (from-to)128-139
JournalClinica e Investigacion en Arteriosclerosis
Volume31
DOIs
Publication statusPublished - 1 May 2019

Keywords

  • Cardiovascular disease
  • Clinical indications
  • Colesterol
  • Consensus document
  • Familial hypercholesterolemia
  • Low density lipoprotein
  • Number needed to treat
  • Proprotein convertase subtilisin kexin 9 inhibitors
  • Treatment

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