Indication for a Single Postoperative Instillation of Chemotherapy in Non–muscle-invasive Bladder Cancer: What Factors Should Be Considered?

Marko Babjuk, Maximilian Burger, Eva M. Compérat, Paolo Gontero, Hugh A. Mostafid, Joan Palou, Bas W.G. van Rhijn, Morgan Rouprêt, Shahrokh F. Shariat, Richard Sylvester, Richard Zigeuner, Otakar Capoun, Daniel Cohen, José L. Dominguez-Escrig, Virginia Hernández, Benoit Peyronnet, Thomas Seisen, Viktor Soukup

    Research output: Contribution to journalArticleResearchpeer-review

    Abstract

    © 2018 European Association of Urology An early single instillation of intravesical chemotherapy (SICI) used immediately after transurethral resection of the bladder (TURB) can significantly reduce the recurrence rate in selected patients with non–muscle-invasive bladder cancer (NMIBC). SICI should be used in patients with low-risk and with selected intermediate-risk tumours, in particular for multiple primary small papillary tumours, single primary papillary tumours >3 cm, and single recurrent papillary tumours recurring >1 yr after the previous resection. The available data do not support any recommendation to reduce the role of SICI in patients after fluorescence cystoscopy–guided TURB or en bloc TURB. SICI can even provide some benefit in patients with intermediate-risk tumours subsequently treated with further instillations. During instillation, contraindications should be taken into account and safety measures should be applied. Patient summary: An early single instillation of intravesical chemotherapy immediately after transurethral resection of the bladder can significantly reduce the recurrence rate in selected patients with non–muscle-invasive bladder cancer. It should be used in patients with low-risk and selected intermediate-risk tumours. An early single instillation of intravesical chemotherapy immediately after transurethral resection of the bladder can significantly reduce the recurrence rate in selected patients with non–muscle-invasive bladder cancer. It should be used in patients with low-risk and selected intermediate-risk tumours.
    Original languageEnglish
    Pages (from-to)525-528
    JournalEuropean Urology Focus
    Volume4
    Issue number4
    DOIs
    Publication statusPublished - 1 Jul 2018

    Keywords

    • Bladder cancer
    • Indication
    • Non–muscle-invasive
    • Single postoperative instillation of chemotherapy

    Fingerprint Dive into the research topics of 'Indication for a Single Postoperative Instillation of Chemotherapy in Non–muscle-invasive Bladder Cancer: What Factors Should Be Considered?'. Together they form a unique fingerprint.

    Cite this