Increased resistance to quinolones in Campylobacter jejuni: A genetic analysis of gyrA gene mutations in quinolone-resistant clinical isolates

Joaquim Ruiz, Pilar Goñi, Francesc Marco, Francesc Gallardo, Beatriz Mirelis, Teresa Jimenez De Anta, Jordi Vila

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92 Citations (Scopus)

Abstract

Campylobacter jejuni is a frequent cause of enteritis and sometimes it requires antimicrobial therapy. We have studied the evolution of resistance to nine antibiotics from 1990 to 1994 and investigated how frequently gyrA mutations are involved in the acquisition of quinolone resistance. The percentage of chloramphenicol-, clindamycin-, tertracycline- and amoxicillin plus clavulanic acid-resistant strains has remained practically unchanged and erythromycin and gentamicin resistance has decreased, whereas the percentage of ampicillin-, nalidixic acid- or ciprofloxacin-resistant strains has almost doubled in the follow-up period, from 56 to 76% for ampicillin- and from 47.5 to 88% for quinolone-resistant strains. This study clearly shows that a mutation in Thr-86 to Ile or Lys is a frequent mechanism associated with the acquisition of a high level of resistance to quinolones in clinical isolates of C. jejuni.
Original languageEnglish
Pages (from-to)223-226
JournalMicrobiology and Immunology
Volume42
Issue number3
DOIs
Publication statusPublished - 1 Jan 1998

Keywords

  • Antibiotics
  • Campylobacter jejuni
  • GyrA
  • Quinolone resistance

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