Increased plasma levels of matrix metalloproteases in the early phase after traumatic brain injury

A. Vilalta, J. Sahuquillo, A. Rosell, M. A. Poca, M. L. Fuertes, M. Riveiro, J. Montaner

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    Abstract

    Matrix metal loproteases (MMPs) are a family of zinc-binding proteolytic enzymes that remodel and maintain the extracellular matrix but can act pathologically in various types of brain injury. The purpose of this study was to determine the temporal profile of matrix metalloprotease levels (MMP-2 and MMP-9) in patients with traumatic brain injury (TBI). Twenty patients with a moderate or severe TBI were included. Three groups (healthy people, polytraumatic patients without TBI and mild TBI patients with normal CT scan) were used as controls. A zymography technique was used to determine levels of MMP-2 and MMP-9 in plasma. A significant increase in plasmatic MMP-9 and MMP-2 levels was observed at baseline determination when compared with healthy volunteers (P<0.001 and P=0.001 respectively), followed by a significant decrease at 24 hours post-TBI (P<0.001 and P=0.018 respectively). The results suggest an implication of MMP-9 and MMP-2 in early systemic and non-systemic inflammatory response following TBI.
    Original languageEnglish
    Pages (from-to)94-102
    JournalPatologia del Aparato Locomotor
    Volume5
    Issue number2
    Publication statusPublished - 1 Oct 2007

    Keywords

    • Blood-brain barrier
    • Cerebral ischemia
    • Inflammation neuroinflammation
    • Matrix metalloproteases
    • Traumatic brain injury

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    Vilalta, A., Sahuquillo, J., Rosell, A., Poca, M. A., Fuertes, M. L., Riveiro, M., & Montaner, J. (2007). Increased plasma levels of matrix metalloproteases in the early phase after traumatic brain injury. Patologia del Aparato Locomotor, 5(2), 94-102.