Increased peripheral α1-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat

Maria Laura Cuffí; Elisabet Vila; Albert Badia

doi:10.1016/0014-2999(89)90641-9

Increased peripheral α₁-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat

Maria Laura Cuffí, Elisabet Vila, Albert Badia

Research output: Contribution to journal › Article › Research › peer-review

1 Citation (Scopus)

Abstract

The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.

Original language	English
Pages (from-to)	111-113
Journal	European Journal of Pharmacology
Volume	168
Issue number	1
DOIs	https://doi.org/10.1016/0014-2999(89)90641-9
Publication status	Published - 1 Sept 1989

Keywords

Pithed rat
Thioridazine
α -Adrenoceptors 1
α -Adrenoceptors 2

Access to Document

10.1016/0014-2999(89)90641-9

Cite this

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title = "Increased peripheral α1-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat",

abstract = "The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. {\textcopyright} 1989.",

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AU - Badia, Albert

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N2 - The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.

AB - The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.

KW - Pithed rat

KW - Thioridazine

KW - α -Adrenoceptors 1

KW - α -Adrenoceptors 2

U2 - 10.1016/0014-2999(89)90641-9

DO - 10.1016/0014-2999(89)90641-9

M3 - Article

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