Increased peripheral α<inf>1</inf>-adrenoceptor sensitivity following chronic thioridazine treatment in the pithed rat

Maria Laura Cuffí, Elisabet Vila, Albert Badia

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    1 Citation (Scopus)

    Abstract

    The effect of chronic treatment (10 days) with thioridazine (25 mg/kg per day, i.p.) on the increase in diastolic blood pressure induced by methoxamine and xylazine was studied in the pithed rat. The dose-response curve for methoxamine, but not for xylazine, was shifted to the left by the neuroleptic. These results indicate that postjunctional α1-adrenoceptors in the rat blood vessels become supersentitive after long-term treatment with thioridazine. © 1989.
    Original languageEnglish
    Pages (from-to)111-113
    JournalEuropean Journal of Pharmacology
    Volume168
    Issue number1
    DOIs
    Publication statusPublished - 1 Sep 1989

    Keywords

    • Pithed rat
    • Thioridazine
    • α -Adrenoceptors 1
    • α -Adrenoceptors 2

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